diff --git a/django/contrib/auth/models.py b/django/contrib/auth/models.py
index 84962b9d0e..5f092f0ae8 100644
--- a/django/contrib/auth/models.py
+++ b/django/contrib/auth/models.py
@@ -1,5 +1,7 @@
+from django.apps import apps
 from django.contrib import auth
 from django.contrib.auth.base_user import AbstractBaseUser, BaseUserManager
+from django.contrib.auth.hashers import make_password
 from django.contrib.contenttypes.models import ContentType
 from django.core.exceptions import PermissionDenied
 from django.core.mail import send_mail
@@ -134,9 +136,13 @@ class UserManager(BaseUserManager):
         if not username:
             raise ValueError('The given username must be set')
         email = self.normalize_email(email)
-        username = self.model.normalize_username(username)
+        # Lookup the real model class from the global app registry so this
+        # manager method can be used in migrations. This is fine because
+        # managers are by definition working on the real model.
+        GlobalUserModel = apps.get_model(self.model._meta.app_label, self.model._meta.object_name)
+        username = GlobalUserModel.normalize_username(username)
         user = self.model(username=username, email=email, **extra_fields)
-        user.set_password(password)
+        user.password = make_password(password)
         user.save(using=self._db)
         return user
 
diff --git a/tests/auth_tests/test_models.py b/tests/auth_tests/test_models.py
index c60b66c993..2379f68b83 100644
--- a/tests/auth_tests/test_models.py
+++ b/tests/auth_tests/test_models.py
@@ -10,8 +10,12 @@ from django.contrib.auth.models import (
 )
 from django.contrib.contenttypes.models import ContentType
 from django.core import mail
+from django.db import connection, migrations
+from django.db.migrations.state import ModelState, ProjectState
 from django.db.models.signals import post_save
-from django.test import SimpleTestCase, TestCase, override_settings
+from django.test import (
+    SimpleTestCase, TestCase, TransactionTestCase, override_settings,
+)
 
 from .models import IntegerUsernameUser
 from .models.with_custom_email_field import CustomEmailField
@@ -101,7 +105,12 @@ class LoadDataWithNaturalKeysAndMultipleDatabasesTestCase(TestCase):
         self.assertEqual(perm_other.content_type_id, other_objects[0].id)
 
 
-class UserManagerTestCase(TestCase):
+class UserManagerTestCase(TransactionTestCase):
+    available_apps = [
+        'auth_tests',
+        'django.contrib.auth',
+        'django.contrib.contenttypes',
+    ]
 
     def test_create_user(self):
         email_lowercase = 'normal@normal.com'
@@ -156,6 +165,30 @@ class UserManagerTestCase(TestCase):
         for char in password:
             self.assertIn(char, allowed_chars)
 
+    def test_runpython_manager_methods(self):
+        def forwards(apps, schema_editor):
+            UserModel = apps.get_model('auth', 'User')
+            user = UserModel.objects.create_user('user1', password='secure')
+            self.assertIsInstance(user, UserModel)
+
+        operation = migrations.RunPython(forwards, migrations.RunPython.noop)
+        project_state = ProjectState()
+        project_state.add_model(ModelState.from_model(User))
+        project_state.add_model(ModelState.from_model(Group))
+        project_state.add_model(ModelState.from_model(Permission))
+        project_state.add_model(ModelState.from_model(ContentType))
+        new_state = project_state.clone()
+        with connection.schema_editor() as editor:
+            operation.state_forwards('test_manager_methods', new_state)
+            operation.database_forwards(
+                'test_manager_methods',
+                editor,
+                project_state,
+                new_state,
+            )
+        user = User.objects.get(username='user1')
+        self.assertTrue(user.check_password('secure'))
+
 
 class AbstractBaseUserTests(SimpleTestCase):