diff --git a/django/http/multipartparser.py b/django/http/multipartparser.py
index 526e161ae4..07a1d676ee 100644
--- a/django/http/multipartparser.py
+++ b/django/http/multipartparser.py
@@ -67,7 +67,10 @@ class MultiPartParser:
             raise MultiPartParserError('Invalid Content-Type: %s' % content_type)
 
         # Parse the header to get the boundary to split the parts.
-        ctypes, opts = parse_header(content_type.encode('ascii'))
+        try:
+            ctypes, opts = parse_header(content_type.encode('ascii'))
+        except UnicodeEncodeError:
+            raise MultiPartParserError('Invalid non-ASCII Content-Type in multipart: %s' % force_str(content_type))
         boundary = opts.get('boundary')
         if not boundary or not cgi.valid_boundary(boundary):
             raise MultiPartParserError('Invalid boundary in multipart: %s' % force_str(boundary))
diff --git a/tests/requests/tests.py b/tests/requests/tests.py
index 945d77ff6e..a97b98e8a2 100644
--- a/tests/requests/tests.py
+++ b/tests/requests/tests.py
@@ -487,6 +487,17 @@ class RequestsTests(SimpleTestCase):
         with self.assertRaisesMessage(MultiPartParserError, 'Invalid boundary in multipart: None'):
             request.POST
 
+    def test_multipart_non_ascii_content_type(self):
+        request = WSGIRequest({
+            'REQUEST_METHOD': 'POST',
+            'CONTENT_TYPE': 'multipart/form-data; boundary = \xe0',
+            'CONTENT_LENGTH': 0,
+            'wsgi.input': FakePayload(),
+        })
+        msg = 'Invalid non-ASCII Content-Type in multipart: multipart/form-data; boundary = à'
+        with self.assertRaisesMessage(MultiPartParserError, msg):
+            request.POST
+
     def test_POST_connection_error(self):
         """
         If wsgi.input.read() raises an exception while trying to read() the