diff --git a/django/db/models/sql/query.py b/django/db/models/sql/query.py
index 43cb9d71b55..341765c6083 100644
--- a/django/db/models/sql/query.py
+++ b/django/db/models/sql/query.py
@@ -1475,6 +1475,13 @@ class Query(object):
         query.bump_prefix()
         query.clear_ordering(True)
         query.set_start(prefix)
+        # Adding extra check to make sure the selected field will not be null
+        # since we are adding a IN <subquery> clause. This prevents the
+        # database from tripping over IN (...,NULL,...) selects and returning
+        # nothing
+        alias, col = query.select[0]
+        query.where.add((Constraint(alias, col, None), 'isnull', False), AND)
+
         self.add_filter(('%s__in' % prefix, query), negate=True, trim=True,
                 can_reuse=can_reuse)
 
diff --git a/tests/regressiontests/null_queries/tests.py b/tests/regressiontests/null_queries/tests.py
index 72dcd5153cf..8392c588e4c 100644
--- a/tests/regressiontests/null_queries/tests.py
+++ b/tests/regressiontests/null_queries/tests.py
@@ -67,3 +67,15 @@ class NullQueriesTests(TestCase):
             ['<Inner: Inner object>']
         )
 
+        # Ticket #13815: check if <reverse>_isnull=False does not produce
+        # faulty empty lists
+        objB = OuterB.objects.create(data="reverse")
+        self.assertQuerysetEqual(
+            OuterB.objects.filter(inner__isnull=False),
+            []
+        )
+        Inner.objects.create(first=obj)
+        self.assertQuerysetEqual(
+            OuterB.objects.exclude(inner__isnull=False),
+            ['<OuterB: OuterB object>']
+        )