diff --git a/django/http/__init__.py b/django/http/__init__.py
index 7c6b8f9a0f..92c38c0ad6 100644
--- a/django/http/__init__.py
+++ b/django/http/__init__.py
@@ -263,6 +263,9 @@ def parse_cookie(cookie):
         cookiedict[key] = c.get(key).value
     return cookiedict
 
+class BadHeaderError(ValueError):
+    pass
+
 class HttpResponse(object):
     """A basic HTTP response, with content and dictionary-accessed headers."""
 
@@ -301,6 +304,8 @@ class HttpResponse(object):
     def _convert_to_ascii(self, *values):
         """Converts all values to ascii strings."""
         for value in values:
+            if '\n' in value or '\r' in value:
+                raise BadHeaderError("Header values can't contain newlines (got %r)" % (value))
             if isinstance(value, unicode):
                 try:
                     yield value.encode('us-ascii')
diff --git a/docs/ref/request-response.txt b/docs/ref/request-response.txt
index 6b29b3bb61..8701c76235 100644
--- a/docs/ref/request-response.txt
+++ b/docs/ref/request-response.txt
@@ -445,6 +445,11 @@ To set a header in your response, just treat it like a dictionary::
     >>> response = HttpResponse()
     >>> response['Pragma'] = 'no-cache'
 
+.. versionadded:: 1.1
+
+HTTP headers cannot contain newlines. An attempt to set a header containing a
+newline character (CR or LF) will raise ``BadHeaderError``
+
 Telling the browser to treat the response as a file attachment
 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
 
diff --git a/tests/regressiontests/httpwrappers/tests.py b/tests/regressiontests/httpwrappers/tests.py
index 15b872821c..04099be16e 100644
--- a/tests/regressiontests/httpwrappers/tests.py
+++ b/tests/regressiontests/httpwrappers/tests.py
@@ -444,6 +444,17 @@ Traceback (most recent call last):
 ...
 UnicodeEncodeError: ..., HTTP response headers must be in US-ASCII format
 
+# Bug #10188: Do not allow newlines in headers (CR or LF)
+>>> r['test\\rstr'] = 'test'
+Traceback (most recent call last):
+...
+BadHeaderError: Header values can't contain newlines (got 'test\\rstr')
+
+>>> r['test\\nstr'] = 'test'
+Traceback (most recent call last):
+...
+BadHeaderError: Header values can't contain newlines (got 'test\\nstr')
+
 #
 # Regression test for #8278: QueryDict.update(QueryDict)
 #