diff --git a/django/db/models/constraints.py b/django/db/models/constraints.py
index c6dd39e762..fd01ec5a11 100644
--- a/django/db/models/constraints.py
+++ b/django/db/models/constraints.py
@@ -95,6 +95,14 @@ class UniqueConstraint(BaseConstraint):
             raise ValueError(
                 'UniqueConstraint with conditions cannot be deferred.'
             )
+        if include and deferrable:
+            raise ValueError(
+                'UniqueConstraint with include fields cannot be deferred.'
+            )
+        if opclasses and deferrable:
+            raise ValueError(
+                'UniqueConstraint with opclasses cannot be deferred.'
+            )
         if not isinstance(deferrable, (type(None), Deferrable)):
             raise ValueError(
                 'UniqueConstraint.deferrable must be a Deferrable instance.'
diff --git a/tests/constraints/tests.py b/tests/constraints/tests.py
index 4ec1f2a8e8..d9e91bdf49 100644
--- a/tests/constraints/tests.py
+++ b/tests/constraints/tests.py
@@ -406,6 +406,26 @@ class UniqueConstraintTests(TestCase):
                 deferrable=models.Deferrable.DEFERRED,
             )
 
+    def test_deferrable_with_include(self):
+        message = 'UniqueConstraint with include fields cannot be deferred.'
+        with self.assertRaisesMessage(ValueError, message):
+            models.UniqueConstraint(
+                fields=['name'],
+                name='name_inc_color_color_unique',
+                include=['color'],
+                deferrable=models.Deferrable.DEFERRED,
+            )
+
+    def test_deferrable_with_opclasses(self):
+        message = 'UniqueConstraint with opclasses cannot be deferred.'
+        with self.assertRaisesMessage(ValueError, message):
+            models.UniqueConstraint(
+                fields=['name'],
+                name='name_text_pattern_ops_unique',
+                opclasses=['text_pattern_ops'],
+                deferrable=models.Deferrable.DEFERRED,
+            )
+
     def test_invalid_defer_argument(self):
         message = 'UniqueConstraint.deferrable must be a Deferrable instance.'
         with self.assertRaisesMessage(ValueError, message):