diff --git a/django/db/models/fields/related_descriptors.py b/django/db/models/fields/related_descriptors.py
index 451d0b4e1f..20f247c603 100644
--- a/django/db/models/fields/related_descriptors.py
+++ b/django/db/models/fields/related_descriptors.py
@@ -697,6 +697,10 @@ def create_reverse_many_to_one_manager(superclass, rel):
                 val = self.field.get_foreign_related_value(self.instance)
                 old_ids = set()
                 for obj in objs:
+                    if not isinstance(obj, self.model):
+                        raise TypeError("'%s' instance expected, got %r" % (
+                            self.model._meta.object_name, obj,
+                        ))
                     # Is obj actually part of this descriptor set?
                     if self.field.get_local_related_value(obj) == val:
                         old_ids.add(obj.pk)
diff --git a/tests/many_to_one/tests.py b/tests/many_to_one/tests.py
index d769b206b9..76ef4921dd 100644
--- a/tests/many_to_one/tests.py
+++ b/tests/many_to_one/tests.py
@@ -733,3 +733,14 @@ class ManyToOneTests(TestCase):
         child = parent.to_field_children.get()
         with self.assertNumQueries(0):
             self.assertIs(child.parent, parent)
+
+    def test_add_remove_set_by_pk_raises(self):
+        usa = Country.objects.create(name='United States')
+        chicago = City.objects.create(name='Chicago')
+        msg = "'City' instance expected, got %s" % chicago.pk
+        with self.assertRaisesMessage(TypeError, msg):
+            usa.cities.add(chicago.pk)
+        with self.assertRaisesMessage(TypeError, msg):
+            usa.cities.remove(chicago.pk)
+        with self.assertRaisesMessage(TypeError, msg):
+            usa.cities.set([chicago.pk])