diff --git a/django/templatetags/cache.py b/django/templatetags/cache.py
index 9c6ca76854..387dd8721c 100644
--- a/django/templatetags/cache.py
+++ b/django/templatetags/cache.py
@@ -3,6 +3,7 @@ from django.template import resolve_variable
 from django.core.cache import cache
 from django.utils.encoding import force_unicode
 from django.utils.http import urlquote
+from django.utils.hashcompat import md5_constructor
 
 register = Library()
 
@@ -23,7 +24,8 @@ class CacheNode(Node):
         except (ValueError, TypeError):
             raise TemplateSyntaxError('"cache" tag got a non-integer timeout value: %r' % expire_time)
         # Build a unicode key for this fragment and all vary-on's.
-        cache_key = u':'.join([self.fragment_name] + [urlquote(resolve_variable(var, context)) for var in self.vary_on])
+        args = md5_constructor(u':'.join([urlquote(resolve_variable(var, context)) for var in self.vary_on]))
+        cache_key = 'template.cache.%s.%s' % (self.fragment_name, args.hexdigest())
         value = cache.get(cache_key)
         if value is None:
             value = self.nodelist.render(context)
diff --git a/tests/regressiontests/templates/tests.py b/tests/regressiontests/templates/tests.py
index 901ef39796..9c01b492e3 100644
--- a/tests/regressiontests/templates/tests.py
+++ b/tests/regressiontests/templates/tests.py
@@ -1014,6 +1014,9 @@ class Templates(unittest.TestCase):
             # Regression test for #7460.
             'cache16': ('{% load cache %}{% cache 1 foo bar %}{% endcache %}', {'foo': 'foo', 'bar': 'with spaces'}, ''),
 
+            # Regression test for #11270.
+            'cache17': ('{% load cache %}{% cache 10 long_cache_key poem %}Some Content{% endcache %}', {'poem': 'Oh freddled gruntbuggly/Thy micturations are to me/As plurdled gabbleblotchits/On a lurgid bee/That mordiously hath bitled out/Its earted jurtles/Into a rancid festering/Or else I shall rend thee in the gobberwarts with my blurglecruncheon/See if I dont.'}, 'Some Content'),
+
             ### AUTOESCAPE TAG ##############################################
             'autoescape-tag01': ("{% autoescape off %}hello{% endautoescape %}", {}, "hello"),
             'autoescape-tag02': ("{% autoescape off %}{{ first }}{% endautoescape %}", {"first": "<b>hello</b>"}, "<b>hello</b>"),